Noncovalent Adsorption of Single-Stranded and Double-Stranded DNA on the Surface of Gold Nanoparticles

Understanding the patterns of noncovalent adsorption double-stranded nucleic acids (dsDNA) on gold nanoparticles (GNPs) was aim this study. It found that high-affinity motifs in DNA can and do act as an “anchor” for fixation whole molecule GNP (up to 98 ± 2 single-stranded (ss)DNA molecules per particle with diameter 13 nm). At same time, involvement intramolecular interaction negatively affect efficiency formation ss(ds)DNA–GNP structures. has been shown duplexes is accompanied by their dissociation competitive ssDNAs GNP, wherein crucial factor intrinsic affinity ssDNA GNP. We propose a detailed scheme dsDNA GNPs, which should be taken into account studies type. Researchers focused field accept complicated nature such objects take many competing processes, including processes desorption well secondary structures individual strands.